Open-access Cone degeneration in two Shih Tzu dogs: clinical and genetic investigation

Degeneração de cones em dois cães da raça Shih Tzu: avaliação clínica e genética

Two cases of cone degeneration in adult Shih Tzu canine patients are reported herein. Definitive diagnosis was made based on the ophthalmic examination finding, typical clinical signs, and characteristic electroretinography results that demonstrated normal rod function and absence of recordable cone function. Sanger sequencing of the entire coding sequence of the cyclic nucleotide gated channel β3 (CNGB3) gene did not reveal disease causing variants in these dogs. To the authors’ knowledge, this is the first report of clinical, electroretinographic and genetic investigation of cone degeneration in Shih Tzu.

Key words:
cone degeneration; achromatopsia; hemeralopia; day blindness; Shih Tzu; electroretinogram

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Universidade Federal de Santa Maria Universidade Federal de Santa Maria, Centro de Ciências Rurais , 97105-900 Santa Maria RS Brazil , Tel.: +55 55 3220-8698 , Fax: +55 55 3220-8695 - Santa Maria - RS - Brazil
E-mail: cienciarural@mail.ufsm.br
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