Neurological complications after H1N1 influenza
vaccinationSir, the report on “neurological complications after H1N1 influenza vaccination1” is very interesting. Lessa et al. reported that “H1N1 vaccination can result in important neurological complications probably secondary to post-vaccination inflammation1” and “MRI detected abnormalities in all patients1.” In fact, the neurological problem can be seen in H1N1 influenza and the MRI finding in the infected case is noted2. The “diffuse prolonged T1 and T2 signal” is the main observation and this is the similar finding to the present described finding in post H1N1 influenza vaccination neurological complications1. In the pharmacovigilance report, the myelin disorder, as detected by MRI finding1, is the common adverse effect reaction due to H1N1 influenza vaccination3. Conclusively, MRI can be the good investigation for determining neurological complication resulted by both influenza infection and vaccination.
References
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1Lessa R, Castillo M, Azevedo R, Azevedo F, Azevedo H. Neurological
complications after H1N1 influenza vaccination: magnetic resonance imaging
findings. Arq Neuropsiquiatr. 2014;72(7):496-9.
http://dx.doi.org/10.1590/0004-282X20140064
» https://doi.org/10.1590/0004-282X20140064 -
2Zeng H, Quinet S, Huang W, Gan Y, Han C, He Y, Wang Y. Clinical and
MRI features of neurological complications after influenza A (H1N1) infection in
critically ill children. Pediatr Radiol. 2013;43(9):1182-9.
http://dx.doi.org/10.1007/s00247-013-2682-5
» https://doi.org/10.1007/s00247-013-2682-5 -
3Durrieu G, Caillet C, Lacroix I, Jacquet A, Faucher A, Quarest S et
al. [National Campaign of Vaccination against the flu A (H1N1)v: National
Follow-up of Pharmacovigilance]. Therapie. 2011;66(6):527-40. French.
http://dx.doi.org/10.2515/therapie/2011075
» https://doi.org/10.2515/therapie/2011075
