Sibship affected by Charcot-Marie-Toot's peroneal muscular atrophy with possible variant of antecipation

Abstract

Considering the genetical peculiarity of Charcot-Marie-Tooth's muscular atrophy, a family with three affected brothers was investigated, in which beginning date was discovered to be progressively antedated. Afterwards, this possible variant of antecipation is discussed, because such condition is quite ununsual, not only in this disease, but in Human Genetics, in a general sense.