Cutaneous leishmaniasis caused by Leishmania infantum arising within a psoriatic plaque: a case reportDear Editor,
Cutaneous leishmaniasis (CL) is a neglected tropical disease with incidence estimates of 700.000 to 1.2 million cases per year; approximately 95% of those cases occur in the Ameri-cas, the Mediterranean basin, the Middle East, and Central Asia.1 Typical clinical presentation varies from single gran-ulomatous lesions or ulcerations on the site of inoculation, but can also resemble other dermatological diseases, such as pyoderma gangrenosum and psoriasis.2,3 However, CL devel-oping in pre-existing skin lesions has rarely been reported. This report describes the first case of an immunocompetent host with the appearance of CL in a longstanding psoriasis plaque.
A 64-year-old Caucasian man presented to the dermatol-ogy department with a painless non-healing wound on his right elbow. He had had psoriasis on this site for 7 years, waxing and waning, and he had noticed some oozing six months before our first consultation, while he was staying in his coastal house south of Valencia, Spain, where he spends several months every winter. He didn’t recall any trauma. He had travelled to Cambodia and Vietnam five years before, but had no recent visits to tropical regions. He was other-wise in good general health. Prior to referral to our tertiary centre, a dermatologist treated him empirically with three courses of antibiotics - amoxicillin-clavulanic acid (dose unspecified) and two other regimens of unknown compo-sition - without improvement. Cultures from the wound and purulent material obtained before the first antibiotic course yielded only normal skin flora. The lesion fluctuated in size, occasionally almost closing but never fully healing. At presentation, his sole therapy was topical disinfection with povidone-iodine solution. Aside from long-standing pso-riasis, his medical history was unremarkable. His chronic medications consisted of rosuvastatin 20 mg once daily and pantoprazole 20 mg once daily.
On dermatological examination, the right elbow dis-played an erythematous, infiltrated lesion with scaling, crusting, slight oozing, and an irregular border, centred within an 8 cm psoriatic plaque (Fig. 1). Classic erythrosqua-mous psoriatic plaques were present on the extensor aspects of both knees and the other elbow, and also the oil-drop pig-mentation of the fingernails was consistent with psoriasis. No hepatomegaly, splenomegaly, or palpable lymphadenopa-thy was detected on physical examination.
Hematic crusts, ulceration and discrete oozing aris-ing within a psoriatic plaque on the right elbow as the first manifestation of CL caused by L. infantum.
The differential diagnosis included atypical pyoderma gangrenosum, deep cutaneous mycosis, cutaneous leishma-niasis (despite weak epidemiological risk), squamous cell carcinoma, and allergic contact dermatitis.
Ultrasound of the upper arm and right axilla demonstrated reactive lymphadenopathy without hep-atosplenomegaly. Routine laboratory tests, including complete blood count and inflammatory markers, were within normal limits.
A punch biopsy from the lesion centre revealed a dense dermal infiltrate of plasma cells and histiocytes forming granulomas; no amastigotes were found. The first PCR determined on a skin sample was positive for Leishmania spp. but lacked species identification. A second biopsy confirmed Leishmania infantum by PCR (Hsp-70 sequencing).4
Following confirmation of the diagnosis and identification of the Leishmania infantum subtype, therapeutic options were carefully evaluated. Because the lesion was located within a psoriatic plaque, local therapy - typically consid-ered first-line in Old World CL standard cases - was not deemed appropriate. The patient was therefore admitted for intravenous amphotericin B at a dosage of 5 mg/kg/day for five consecutive days. This regimen has demonstrated efficacy against L. infantum and is more readily accessi-ble in Belgium compared to pentavalent antimonials, which continue to represent the first-line systemic treatment for cutaneous leishmaniasis in many countries.5 The crusting and oozing subsided completely within six weeks. However, the original psoriasis lesion persisted; to treat the remaining psoriatic plaques on the right elbow and other body sites, a topical spray of calcipotriol + betamethasone dipropionate was applied once daily for two weeks, then tapered to a maintenance schedule. All psoriasis lesions improved within two months.
CL arising within psoriatic plaques is exceedingly rare. To date, only one comparable case has been reported: a 42-year-old Italian man on long-term methotrexate and adalimumab who developed multiple ulcerations within his psoriatic lesions.6 Tumour necrosis factor-a inhibitors are well-recognized risk factors for granulomatous infections, including leishmaniasis.7 Our patient was immunocompe-tent.
CL often mimics a range of dermatoses, but its emer-gence within pre-existing skin lesions is exceptionally rare, underscoring the uniqueness of this case. Equally note-worthy is the culprit species - Leishmania infantum -traditionally linked to visceral disease yet increasingly impli-cated in cutaneous infections in Spain, amongst other countries in the Mediterranean region.8,9 This trend high-lights the importance of including CL in the differential diagnosis of chronic skin lesions in patients with a history of travel to Spain, even in the absence of journeys to classic endemic hotspots.
Research data availability
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References
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Editor
Sílvio Alencar Marques.
