Mecanismo de ação dos sulfamídicos de ação retardadaAbstract
The author summarizes some recent advances in the knowledge of the mecanism of action of the long acting sulfonamides. Particular attention was devoted to the pharmacokinetic characteristics of the sulfamethoxypyrazine. The low elimination rate and the reduced protein binding of this compound as well as its high antibacterial properties and low toxicity allow the achievement of the therapeutic result through the administration of very low doses.