MicroRNAs, cancer and ionizing radiation: Where are we?

Marta, Gustavo Nader; Garicochea, Bernardo; Carvalho, André Lopes; Real, Juliana M.; Kowalski, Luiz Paulo

doi:10.1590/1806-9282.61.03.275

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REVIEW ARTICLES • Rev. Assoc. Med. Bras. 61 (3) • May-Jun 2015 • https://doi.org/10.1590/1806-9282.61.03.275 linkcopy

MicroRNAs, cancer and ionizing radiation: Where are we?

MicroRNAs, câncer e radiação ionizante: em que ponto estamos?

Authorship SCIMAGO INSTITUTIONS RANKINGS

The aim of this study is to describe the biogenesis of microRNA, its relations with carcinogenesis, and the correlation between microRNA and ionizing radiation (IR), focusing on radioresponsiveness. It is known that microRNA biogenesis is well established and involves different enzymatic cleavages, resulting in the production of mature microRNA. MicroRNAs are involved in carcinogenesis. Their interaction is related to the genetic and epigenetic changes associated with activation of proto-oncogenes or inactivation of tumor suppressor genes. Several studies have shown that the levels of expression of some microRNAs vary significantly after irradiation. There are evidences that microRNAs can influence cellular response after IR. In addition, microRNAs are related to modulation of the expression of several post-transcriptional targets in DNA damage response pathways, and to the DNA damage repair regulation mechanism. Future studies can clarify a possible clinical use of microRNAs as a new class of radiosensitive agents.

Keywords:
microRNAs; radiotherapy; neoplasms

Cell type	Increase	Decrease
Central nervous system
Glioma³¹ ^, ³² ^, ³³	let-7a; let-7b; let-7c; let-7d; let-7e; let-7f; let-7g; let-7i; miR-15a;	miR-107; miR-181a; miR-521
	miR-16; miR-17-3p; miR-17-5p; miR-19a; miR-19b; miR-22;
	miR-21; miR-142-3p; miR-142-5p; miR-143; miR-155; miR-191;
	miR-379; miR-601
Mouse hippocampal cells and brain tissue³⁴	miR-21	–
Head and neck
Thyroid³⁵ ^, ³⁶	let-7c; let-7d; let-7g; miR-17-3p; miR-17-5p; miR-27b;	let-7f; let-7g; miR-10a; miR-106a; miR-152
	miR-34a; miR-34b; miR-188-5p; miR-365
Thorax
Lung cancer and normal epithelial cell line³⁷ ^, ³⁸ ^, ³⁹	miR-15a; miR-16; miR-17-5p; miR-19a; miR-19b; miR-20b;	let-7a; let-7b; let-7c; let-7d; let-7e; let-7f;
	miR-22; miR-24; miR-27a; miR-27b; miR-30a-5p; miR-99a;	let-7i; miR-26b; miR-125a; miR-155;
	miR-106a; miR-148a; miR-221; miR-365; miR-126; let-7a;	miR 130a, miR-106b, miR-19b, miR-22,
	miR-495; miR-451; miR-128b	iR-15b, miR-17-5p; miR-21
Genitourinary
Prostate⁴⁰ ^, ⁴¹ ^, ⁴²	miR-191; miR-379; miR-29b 7; miR-191; miR-22; miR-200c;	miR-100; miR-107; miR-133b; miR-143;
	miR-191; miR-379; miR-29b 7; miR-191; miR-22; miR-200c;	miR-145; miR-196a; miR-521; miR-106b;
	miR-141; miR-24 ; miR-30a-5p; miR-9-1	miR-199a
Gastrointestinal
Rectum⁴³ ^, ⁴⁴	miR-1183; miR-483-5p; miR-622; miR-125a-3p; miR-1224-5p;	miR-1274b; miR-720
	miR-188-5p; miR-1471; miR-671-5p; miR-1909; miR-630;
	miR-765; miR125b; miR137
Hematology
Non-Hodgkin lymphoma⁴⁵	miR-1913; miR-Plus-F1147; miR-148b; miR-589; miR-106b;	miR-29a; miR-335; miR-193b; miR-21;
	miR-Plus-G1246-3p; miR-19b; miR-1280; miR-BHRF1-1;	miR-340; miR-33a; let-7e; miR-Plus-E1098;
	miR-20a	miR-483-3p; miR-200b
Breast
Breast⁴⁶	–	miR-302a; miR-302b; miR-302c;
Breast⁴⁶	–	miR-302d; miR-302e
Other
Normal human fibroblasts⁴⁷	let-7d; let-7e; let-7f; let-7g; let-7i; miR-15a; miR-17-3p; miR-17-5p;	let-7a; let-7b; let-7d; miR-24; miR-155;
	miR-19b; miR-21; miR-26b; miR-142-3p; miR-142-5p; miR-143;	miR-222
	miR-145; miR-155; miR-663
Human 3-D airway model tissues⁴⁸	–	let-7a; let-7b; let-7c; let-7d; let-7e;
Human 3-D airway model tissues⁴⁸	–	let-7f; let-7g; let-7i
Lymphocytes⁴⁹	miR-16; miR-34a; miR-34b; miR-145; miR-188-5p; miR-221;	let-7e; miR-10a; miR-17; miR-19b; miR-99a;
	miR-601; miR-663	miR-100; miR-152;miR-181a; miR-196a
Blood⁵⁰	let-7f; miR-16; miR-17-3p; miR-17-5p; miR-19a; miR-20a;	miR-143
	miR-20b; miR-21; miR-24; miR-27a; miR-29a; miR-29c;
	miR-106a; miR-126; miR-142-5p; miR-145; miR-148a;
	miR-222
Endothelial cell⁵¹	let-7g; miR-16; miR-20a; miR-21; miR-29c	miR-125a
Human umbilical vein endothelial cells⁵²	miR-17-5p; miR-19a; miR-19b; miR-20a; miR-21; miR-27b;	–
	miR-29a; miR-29c; miR-126; miR-221; miR-222

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