Nitration of phenol, a method on semi-micro scale for a 4 hours laboratory

Abstract

A procedure for the nitration of phenol in a semi-micro scale, followed by separation of the formed orto- and para-nitrophenol isomers by column chromatography, is described. All the experiment, including determination of the melting point of the isolated products, require a period of 4 hours, and it is suitable for organic chemistry laboratory undergraduate courses.

nitration of phenol; semi-micro scale; chemical education