person Afonso S. M. M. Velez
Visualization · writing original draft and editing
received his BS degree in Chemistry from the Federal Rural University of Rio de Janeiro (2019); a master’s degree in chemistry from the same University (2021). Nowadays, he is a PhD student (PPGQ-UFRRJ) working on the design, synthesis and antichagasic evaluation of new piperine-nitroimidazole hybrids, under the supervision of Prof Marco E. F. Lima and co-supervision of Prof Débora Decoté-Ricardo.
schoolDepartamento de Química Orgânica, Instituto de Química, Universidade Federal Rural do Rio de Janeiro, 23890-000 Seropédica-RJ, BrazilUniversidade Federal Rural do Rio de JaneiroBrazilSeropédica, RJ, BrazilDepartamento de Química Orgânica, Instituto de Química, Universidade Federal Rural do Rio de Janeiro, 23890-000 Seropédica-RJ, Brazil
person Paulo Pitasse-Santos
Writing – review and editing
received a BS degree in Chemical Engineering (2014) and a master’s degree in Chemistry (2017) from the Federal Rural University of Rio de Janeiro (UFRRJ, Brazil). He got a PhD degree in Chemistry from the PPGQ-UFRRJ (2022) working with cell-penetrating antimicrobial peptides and peptide-drug conjugates under the supervision of Prof Marco E. F. Lima, with a sandwich period at Purdue University (Indiana, USA), under the supervision of Prof Jean Chmielewski. He is currently working as a Postdoctoral Research Associate with the design and synthesis of molecular glues related to 14-3-3 protein-protein interactions, under the supervision of Dr Richard Doveston, at the University of Leicester (United Kingdom).
schoolLeicester Institute of Structural and Chemical Biology and School of Chemistry, University of Leicester, LE1 7RH Leicester, UKUniversity of LeicesterUnited KingdomLeicester, United KingdomLeicester Institute of Structural and Chemical Biology and School of Chemistry, University of Leicester, LE1 7RH Leicester, UK
person Leonardo Freire-de-Lima
data curation · Visualization · writing-review
is assistant professor at Federal University of Rio de Janeiro. During his scientific career, he worked in projects related to cellular interactions mediated by carbohydrates, glycoimmunology of infectious diseases, as well as glycobiology of cancer cells. So far, the obtained results and the ongoing experiments in his lab aim to determine the role of oncofetal glycoproteins and/or glycosyltransferases in many events related to cancer progression, opening the possibility of discovering new targets and/or therapeutic strategies for the treatment of cancer.
schoolInstituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Ilha do Fundão, 21941-902 Rio de Janeiro-RJ, BrazilUniversidade Federal do Rio de JaneiroBrazilRio de Janeiro, RJ, BrazilInstituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Ilha do Fundão, 21941-902 Rio de Janeiro-RJ, Brazil
person Célio G. Freire-de-Lima
data curation · Visualization · writing-review
is a professor in the Program de Imunobiologia at the Instituto de Biofísica Carlos Chagas Filho at Universidade Federal do Rio de Janeiro, has a PhD from the Instituto de Microbiologia Paulo de Goes at UFRJ and a Post-Doctorate from the National Jewish Medical and Research Center in Denver, Colorado. Dr Freire-de-Lima is the head of the Immunomodulation Laboratory (LABIM) of the IBCCF/UFRJ. The Lab’s thematic lines have been concentrated in the areas of Immunology, Microbiology and Experimental Medicine, evaluating the immunomodulatory mechanisms triggered by parasitic infection and/or purified molecules. Briefly, the Laboratory investigates the importance of cellular components of the innate response in regulating immunity. For example, the phagocytosis of apoptotic cells by macrophages and the involvement of B-1 cells and their secreted products in models of infectious and inflammatory diseases. Furthermore, our group described the involvement of capsular components of the opportunistic fungus Cryptococcus neoformans in modulating the immune response and consequently in the course of infection. The Immunomodulation Laboratory also collaborates with different research groups. Furthermore, it is important to highlight that the laboratory is committed to training future professionals who can contribute in a relevant way to the progress of science.
schoolInstituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Ilha do Fundão, 21941-902 Rio de Janeiro-RJ, BrazilUniversidade Federal do Rio de JaneiroBrazilRio de Janeiro, RJ, BrazilInstituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Ilha do Fundão, 21941-902 Rio de Janeiro-RJ, Brazil
person Debora Decoté-Ricardo
data curation · Visualization · writing-review
is an associate professor responsible for the disciplines of Basic Immunology, Clinical Immunology and Immunotherapy in the Department of Microbiology and Veterinary Immunology of Veterinary Institute at the Federal Rural University of Rio de Janeiro (Brazil). She worked as a visiting researcher at the Integrated Department of Immunology at National Jewish Health, Denver, Colorado, USA (2005-2006) under the supervision of Dr John Cambier. She received her PhD in science (2008) at the Federal University of Rio de Janeiro. Her area of expertise is the modulation of the immune response in models of infection and autoimmunity. Among the infection models, she has long experience in the study of parasitic diseases such as those caused by protozoa and fungi, always focusing on immunomodulation strategies by regulating the immune system through humoral, cellular therapies or the use of natural products. Likewise, studies have been carried out on the modulation of inflammatory responses resulting from autoimmunity.
schoolDepartamento de Microbiologia e Imunologia Veterinária, Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro, 23890-000 Seropédica-RJ, BrazilUniversidade Federal Rural do Rio de JaneiroBrazilSeropédica, RJ, BrazilDepartamento de Microbiologia e Imunologia Veterinária, Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro, 23890-000 Seropédica-RJ, Brazil
person Marco E. F. de Lima
*
Conceptualization · Validation · data curation · editing, and writing-review
is a full professor in the Department of Organic Chemistry of the Institute of Chemistry at the Federal Rural University of Rio de Janeiro (Seropédica, RJ, Brazil). He worked as a visiting researcher at Prof Victor Hruby’s group (2015-2016) at the University of Arizona (Tucson, AZ, USA) on the design and synthesis of peptides for medicinal purposes. Prof Lima received his PhD in sciences (1994) from IQ-UFRJ working under the supervision of Prof Andrew E. Greene at LEDSS-3 (University of Grenoble-France, 1991-1993) in the total synthesis of natural products using the [2 + 2] cycloaddition reaction of dichloroketene to olefins. He got a master’s in sciences degree (1989) from IQ-UFRJ working on the design and synthesis of new anti-inflammatory drugs under the supervision of Prof Eliezer J. Barreiro; and he got a BS degree in Pharmacy from the School of Pharmacy of the Federal University of Rio de Janeiro (1986). Prof Lima’s research interests include the medicinal chemistry of natural products, focusing the design and synthesis of new chemical entities potentially useful as antiparasitic drugs with a major emphasis on neglected tropical diseases.
schoolDepartamento de Química Orgânica, Instituto de Química, Universidade Federal Rural do Rio de Janeiro, 23890-000 Seropédica-RJ, BrazilUniversidade Federal Rural do Rio de JaneiroBrazilSeropédica, RJ, BrazilDepartamento de Química Orgânica, Instituto de Química, Universidade Federal Rural do Rio de Janeiro, 23890-000 Seropédica-RJ, Brazil
Editor handled this article: Hector Henrique F. Koolen (Associate)
Seasoning to Kill: the Example of the Natural Amide Piperine and Its Potential in the Design of New Antiparasitic Drugs
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