Comparison of tooth movement and biological response resulting from different force magnitudes combined with osteoperforation in rabbits

HUANG, Cheng-Yi; LU, Hai-Ping; YU, Yu-Feng; DING, Xi; ZHANG, Zan-Zan; ZHANG, Jia-Nan

doi:10.1590/1678-7757-2020-0734

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Original Article • J. Appl. Oral Sci. 29 • 2021 • https://doi.org/10.1590/1678-7757-2020-0734 linkcopy

Comparison of tooth movement and biological response resulting from different force magnitudes combined with osteoperforation in rabbits

Authorship SCIMAGO INSTITUTIONS RANKINGS

Objective To compare tooth movement rate and histological responses with three different force magnitude designs under osteoperforation in rabbit models.

Methodology 48 rabbits were divided into three groups: Group A, Group B, and Group C, with traction force of 50 g, 100 g, 150 g, respectively. Osteoperforation was performed at the mesial of the right mandibular first premolar, the left side was not affected. One mini-screw was inserted into bones between two central incisors. Coil springs were fixed to the first premolars and the mini-screw. Tooth movement distance was calculated, and immunohistochemical staining of PCNA, OCN, VEGF, and TGF-β1 was analyzed.

Results The tooth movement distance on the surgical side was larger than the control side in all groups (P<0.01). No significant intergroup difference was observed for the surgical side in tooth movement distance among the three groups (P>0.05). For the control side, tooth movement distance in Group A was significantly smaller than Groups B and C (P<0.001); no significant difference in tooth movement distance between Group B and Group C was observed (P>0.05). On the tension area of the moving premolar, labeling of PCNA, OCN, VEGF and TGF-β1 were confirmed in alveolar bone and periodontal ligament in all groups. PCNA, OCN, VEGF and TGF-β1 on the surgical side was larger than the control side in all groups (P<0.001).

Conclusion Osteoperforation could accelerate orthodontic tooth movement rate in rabbits. Fast osteoperforation-assisted tooth movement in rabbits was achieve with light 50 g traction.

Osteoperforation; Tooth movement; Biological response; Force

	Control Side	Surgical Side	P
GA	0.52±0.08	1.02±0.17	0.000^‡
GB	0.74±0.13	1.02±0.14	0.000^‡
GC	0.73±0.14	1.03±0.27	0.001^†
PAB	0.000^‡	0.947*
PAC	0.000^‡	0.878*
PBC	0.735*	0.834*

	PCNA			OCN			VEGF			TGF-β1
	Control Side	Surgical Side	P	Control Side	Surgical Side	P	Control Side	Surgical Side	P	Control Side	Surgical Side	P
GA	0.065±0.002	0.076±0.002	0.000^‡	0.141±0.004	0.221±0.004	0.000^‡	0.009±0.007	0.012±0.005	0.000^‡	0.155±0.002	0.230±0.002	0.000^‡
GB	0.070±0.002	0.075±0.001	0.000^‡	0.183±0.004	0.225±0.003	0.000^‡	0.012±0.005	0.014±0.004	0.000^‡	0.183±0.001	0.254±0.002	0.000^‡
GC	0.070±0.001	0.076±0.001	0.000^‡	0.184±0.003	0.225±0.002	0.000^‡	0.012±0.005	0.014±0.003	0.000^‡	0.183±0.002	0.254±0.002	0.000^‡
PAB	0.000^‡	0,47		0.000^‡	0.006^†		0.000^‡	0.000^‡		0.000^‡	0.000^‡
PAC	0.000^‡	0,704		0.000^‡	0.002^†		0.000^‡	0.000^‡		0.000^‡	0.000^‡
PBC	0,542	0,585		0,313	0,713		0,206	0,114		0,549	0,945

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[TFN1] Data are presented as mean±SD; PAB: the difference of tooth movement distance between Group A and Group B; PAC: the difference of tooth movement distance between Group A and Group C; PBC: the difference of tooth movement distance between Group B and Group C; P<0.05, P<0.01 and P<0.001=significant; *: P<0.05; ^†: P<0.01; ^‡: P<0.001.