Synthesis and characterization of platinum (II) complexes containing iodide and furan derivatives as ligands

Abstract

Platinum (II) compounds, for example, cisplatin, carboplatin and oxaloplatin, have been used as chemotherapeutic agents for the treatment of various types of cancer. However, in an attempt to reduce toxicity and widen the spectrum of activity of cisplatin and its analogous, thousands of platinum complexes have been prepared by varying the nature of the leaving groups and the carrier ligands. This work reports the synthesis and characterization of novel structural types of the platinum compounds, having iodide and furan derivatives as ligands. The compounds were characterized using NMR, IR and elemental analysis.

platinum complexes; oximes; semicarbazones; furan