Cortical and subcortical auditory evoked potentials with verbal stimulus: correlation and association in adults

Schumacher, Christine Grellmann; Betti, Tainá; Moreira, Hélinton Goulart; Didoné, Dayane Domeneghini; Garcia, Michele Vargas

doi:10.1590/2317-1782/e20240301en

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Original Article • CoDAS 38 (1) • 2026 • https://doi.org/10.1590/2317-1782/e20240301en linkcopy

Cortical and subcortical auditory evoked potentials with verbal stimulus: correlation and association in adults

Authorship SCIMAGO INSTITUTIONS RANKINGS

Purpose To analyze the correlation and association between the Long Latency Auditory Evoked Potential (LLAEP) and the Frequency Following Response (FFR) in young adults with normal hearing thresholds.

Methods This was a cross-sectional, quantitative, and qualitative study. The sample included 32 young adults (mean age of 22.5 years) of both sexes who met the inclusion criteria. The participants underwent basic audiological evaluation, screening of auditory skills through the Random Gap Detection Test and Dichotic Digits Test, and electrophysiological tests: Auditory Brainstem Response with click stimulus, Long Latency Auditory Evoked Potential, and Frequency Following Response with verbal stimulus.

Results A statistically significant and positive brightness was observed between waves V, A and C and waves P1 and N2, evidencing the participation of auditory structures of the primary auditory cortex in the generation of FFR responses, and a negative appearance between waves C and N2, reflecting the different auditory abilities to generate the responses of each component. There was no significant association between individuals classified as normal and altered in the tests in general performed in the present study or when associated between each component.

Conclusion Waves V, A, and C correlate with waves P1 and N2 of the Long Latency Auditory Evoked Potential in young adults. There was no evidence of associations between the qualitative results of the Frequency Following Response and the Long Latency Auditory Evoked Potential.

Keywords
Hearing; Electrophysiology; Evoked Potentials; Young Adult; Association; Correlation of Data

	N P1		N N1		N P2		N N2		N P3
V	24	r=0.54	30	r=0.21	30	r=0.04	26	r=-0.47	22	r=-0.33
V	24	P = 0.007	30	P = 0.256	30	P = 0.816	26	P = 0.015	22	P = 0.137
A	24	r=0.64	30	r=0.05	30	r=-0.07	26	r=-0.44	22	r=-0.29
A	24	P = 0.001	30	P = 0.784	30	P = 0.708	26	P = 0.023	22	P = 0.193
C	22	r=-0.26	28	r=0.06	28	r=0.29	24	r=0.43	20	r=-0.27
C	22	P = 0.238	28	P = 0.746	28	P = 0.134	24	P = 0.036	20	P = 0.253
D	18	r=0.11	22	r=0.01	22	r=0.20	19	r=0.08	18	r=-0.08
D	18	P = 0.651	22	P = 0.969	22	P = 0.379	19	P = 0.732	18	P = 0.727
E	22	r=0.38	27	r=-0.09	27	r=-0.14	24	r=-0.11	20	r=-0.32
E	22	P = 0.078	27	P = 0.622	27	P = 0.497	24	P = 0.605	20	P = 0. 173
F	23	r=0.10	29	r=0.02	29	r=-0.29	25	r=0.12	21	r=0.01
F	23	P = 0.634	29	P = 0.918	29	P = 0.119	25	P = 0.557	21	P = 0.973
O	23	r=0.35	28	r=0.11	28	r=0.14	24	r=-0.20	21	r=-0.28
O	23	P = 0.105	28	P = 0.596	28	P = 0.489	24	P = 0.356	21	P = 0.213

FFR		P1			N1			P2			N2			P3
		N	A	p-value	N	A	p-value	N	A	p-value	N	A	p-value	N	A	p-value
V	N	23	8	0.557	28	3	0.744	27	4	0.701	25	6	0.625	21	10	0.493
		71.88%	25.00%		87.50%	9.38%		84.38%	12.50%		78.13%	18.75%		65.63%	31.25%
	A	1	0		1	0		1	0		1	0		1	0
		3.13%	0.00%		3.13%	0.00%		3.13%	0.00%		3.13%	0.00%		3.13%	0.00%
A	N	19	7	0.601	23	3	0.382	23	3	0.732	22	4	0.310	17	9	0.392
		59.38%	21.88%		71.88%	9.38%		71.88%	9.38%		68.75%	12.50%		53.13	28.13
	A	5	1		6	0		5	1		4	2		5	1
		15.63%	3.13%		18.75%	0.00%		15.63%	3.13%		12.50%	6.25%		15.63%	3.13%
C	N	22	8	0.400	28	2	0.042	27	3	0.098	24	6	0.483	20	10	0.325
		68.75%	25.00%		87.50%	6.25%		84.38%	9.38%		75.00%	18.75%		62.50%	31.25%
	A	2	0		1	1		1	1		2	0		2	0
		6.25%	0.00%		3.13%	3.13%		3.13%	3.13%		6.25%	0.00%		6.25%	0.00%
D	N	14	4	0.681	17	1	0.401	15	3	0.419	16	2	0.209	12	6	0.773
		43.75%	12.50%		53.13%	3.13%		46.88%	9.38%		50.00%	6.25%		37.50%	18.75%
	A	10	4		12	2		13	1		10	4		10	4
		31.25%	12.50%		37.50%	6.25%		40.63%	3.13%		31.25%	12.50%		31.25%	12.50%
E	N	20	4	0.059	22	2	0.726	22	2	0.217	21	3	0.117	16	8	0.660
		62.50%	12.50%		68.75%	6.25%		68.75%	6.25%		65.63%	9.38%		50.00%	25.00%
	A	4	4		7	1		6	2		5	3		6	2
		12.50%	12.50%		21.88%	3.13%		18.75%	6.25%		15.63%	9.38%		18.75%	6.25%
F	N	17	5	0.660	20	2	0.935	20	2	0.387	19	3	0.272	13	9	0.080
		53.13%	15.63%		62.50%	6.25%		62.50%	6.25%		59.38%	9.38%		40.63%	28.13%
	A	7	3		9	1		8	2		7	3		9	1
		21.88%	9.38%		28.13%	3.13%		25.00%	3.25%		21.88%	9.38%		28.13%	3.13%
O	N	18	6	1.000	22	2	0.726	22	2	0.217	20	4	0.601	17	7	0.660
		56.25%	18.75%		68.75%	6.25%		68.75%	6.25%		62.50%	12.50%		53.13%	21.88%
	A	6	2		7	1		6	2		6	2		5	3
		18.75%	6.25%		21.88%	3.13%		18.75%	6.25%		18.75%	6.25%		15.63%	9.38%

		LLAEP		p-value
		Normal	Altered	0.114
FFR	Normal	7	5
	Normal	21.88%	15.63%
	Altered	6	14
	Altered	18.75%	43.75%

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[1] Caption: N = number of subjects with presence of potential; p = p-value; r = correlation strength. Statistic: Pearson Correlation Test. Bold = statistically significant correlation