Acute-phase proteins in rabbits undergoing laparoscopic cholecystectomy: LigaSure device versus electrosurgery

Machado, Ana Clara Silva; Wittmaack, Mônica Carolina Nery; Vera, Maria Camila Maldonado; Silva, Daniela Gomes da; Sembenelli, Guillherme; Montanhim, Gabriel Luiz; Ido, Cléber Kazuo; Ribeiro, Juliana de Oliveira; Menezes, Mareliza Possa de; Moraes, Paola Castro

doi:10.1590/1809-6891v25e-79416E

person Ana Clara Silva Machado *

Investigation · Methodology · Preview · Writing (original draft)

schoolUniversidade Estadual Paulista “Júlio de Mesquita Filho” (Unesp), Jaboticabal, São Paulo, Brazil

0009-0004-8455-3901

person Mônica Carolina Nery Wittmaack

Conceptualization · Acquisition of financing · Investigation · Writing (review and editing)

schoolUniversidade Estadual Paulista “Júlio de Mesquita Filho” (Unesp), Jaboticabal, São Paulo, Brazil

0000-0001-7191-2320

person Maria Camila Maldonado Vera

Methodology

schoolUniversidade Estadual Paulista “Júlio de Mesquita Filho” (Unesp), Jaboticabal, São Paulo, Brazil

0000-0002-0979-0825

person Daniela Gomes da Silva

Formal analysis · Resources · Writing (review and editing)

schoolUniversidade Estadual Paulista “Júlio de Mesquita Filho” (Unesp), Jaboticabal, São Paulo, Brazil

0000-0002-5232-9516

person Guillherme Sembenelli

Methodology

schoolUniversidade Estadual Paulista “Júlio de Mesquita Filho” (Unesp), Jaboticabal, São Paulo, Brazil

0000-0002-3912-6423

person Gabriel Luiz Montanhim

Methodology

schoolUniversidade Estadual Paulista “Júlio de Mesquita Filho” (Unesp), Jaboticabal, São Paulo, Brazil

0000-0002-9830-041X

person Cléber Kazuo Ido

Conceptualization · Investigation · Methodology

schoolUniversidade Estadual Paulista “Júlio de Mesquita Filho” (Unesp), Jaboticabal, São Paulo, Brazil

0000-0003-2167-6010

person Juliana de Oliveira Ribeiro

Conceptualization · Investigation

schoolUniversidade Estadual Paulista “Júlio de Mesquita Filho” (Unesp), Jaboticabal, São Paulo, Brazil

0000-0002-5393-7476

person Mareliza Possa de Menezes

Conceptualization · Investigation

schoolUniversidade Estadual Paulista “Júlio de Mesquita Filho” (Unesp), Jaboticabal, São Paulo, Brazil

0000-0002-0294-5126

person Paola Castro Moraes

Conceptualization · Acquisition of financing · Investigation · Supervision · Writing (review and editing)

schoolUniversidade Estadual Paulista “Júlio de Mesquita Filho” (Unesp), Jaboticabal, São Paulo, Brazil

0000-0002-0255-2971

person*corresponding author:
acmachado237@hotmail.com

Declaration of conflict of interest

The authors declare that there is no conflict of interest.

Proteins	Evaluation Days
Proteins	D0	D3	D7	D15
Fibrinogen (g/dL)
Group 1	0.20 ± 0.20 ^Aa	0.60 ± 0.28 ^Ab	0.30 ± 0.35 ^Aab	0.40 ± 0.20 ^Aab
Group 2	0.25 ± 0.18 ^Aa	0.70 ± 0.35 ^Ab	0.40 ± 0.20 ^Aab	0.20 ± 0.20 ^Aa
IgA (mg/dL)
Group 1	10.5 ± 2.79 ^Aa	14.4 ± 4.97 ^Aa	11.4 ± 7.25 ^Aa	12.8 ± 13.1 ^Aa
Group 2	12.9 ± 4.44 ^Aa	13.0 ± 3.48 ^Aa	10.6 ± 5.71 ^Aa	10.5 ± 2.29 ^Aa
Ceruloplasmin(mg/dL)
Group 1	16.5 ±5.40 ^Aa	22.1 ± 8.55 ^Aa	18.4 ± 6.50 ^Aa	19.1 ±7.57 ^Aa
Group 2	17.4 ± 3.05 ^Aa	19.9 ± 4.82 ^Aa	14.7 ± 8.71 ^Aa	14.4 ± 11.0 ^Aa
Transferrin (mg/dL)
Group 1	290 ± 41.3 ^Aa	405 ± 90.5 ^Ab	370 ± 51.8 ^Aab	300 ± 89.3 ^Aa
Group 2	325 ± 74.9 ^Aa	390 ± 44.8 ^Ab	359 ± 115 ^Aab	367 ± 79.5 ^Aab
Albumin (mg/dL)
Group 1	5,261 ± 290 ^Aab	5,383 ± 547 ^Aa	4,549 ± 649 ^Abc	4,295 ± 939 ^Ac
Group 2	5,684 ± 607 ^Aa	5,568 ± 354 ^Aab	5,089 ± 588 ^Ab	5,106 ± 376 ^Bb
Haptoglobin (mg/dL)
Group 1	19.8 ± 5.96 ^Aa	32.2 ± 21.4 ^Aa	21.6 ± 9.00 ^Aa	23.8 ± 5.81 ^Aa
Group 2	23.2 ± 3.21 ^Aa	23.7 ± 12.4 ^Aa	20.2 ± 16.1 ^Aa	29.1 ± 9.87 ^Aa
IgG (mg/dL)
Group 1	256 ± 48.3 ^Aab	211 ± 76.4 ^Aa	187 ± 79.2 ^Aa	289 ± 170 ^Ab
Group 2	281 ± 47.5 ^Aa	231 ± 43.3 ^Aab	174 ± 24.4 ^Ab	409 ± 249 ^Aa
α-acid glycoprotein (mg/dL)
Group 1	43.6 ± 8.85 ^Aa	43.2 ± 21.5 ^Aa	29.1 ± 14.9 ^Aa	38.0 ± 18.9 ^Aa
Group 2	46.7 ± 17.2 ^Aa	41.0 ± 19.3 ^Aab	31.0 ± 10.4 ^Ab	40.0 ± 10.8 ^Aab
PM 23.000 Da (mg/dL)
Group 1	57.2 ± 24.6 ^Aa	44.8 ± 13.7 ^Ab	44.0 ± 27.7 ^Aab	67.9 ± 29.5 ^Aa
Group 2	62.0 ± 11.5 ^Aac	36.9 ± 15.2 ^Ab	48.0 ± 15.4 ^Aab	90.4 ± 29.7 ^Ac
CRP (mg/dL)
Group 1	1.50 ± 0.70 ^Aab	5.65 ± 11.3 ^Aa	1.00 ± 3.00 ^Ab	0.90 ± 2.40 ^Ab
Group 2	2.28 ± 1.90 ^Aa	6.00 ± 7.60 ^Ab	4.10 ± 5.95 ^Aab	2.55 ± 2.21 ^Aa

Parameters	IgA	Cerul	Transf	Alb	IgG	Hapto	α1-acid	PM 23.000	CRP
Fib	rho = 0.13 p = 0.2337	rho = 0.11 p = 0.3369	rho = 0.25 p = 0.0269	rho = 0.13 p = 0.2694	rho = −0.24 p = 0.0295	rho = −0.07 p = 0.5513	rho = −0.07 p = 0.5087	rho = −0.41 p = 0.0002	rho = 0.40 p = 0.0010
	IgA	rho = 0.25 p = 0.0267	rho = 0.25 p = 0.0280	rho = 0.20 p = 0.0756	rho = −0.04 p = 0.7035	rho = 0.09 p = 0.4436	rho = 0.16 p = 0.1628	rho = −0.11 p = 0.3103	rho = 0.03 p = 0.7949
		Cerul	rho = −0.03 p = 0.8110	rho = 0.004 p = 0.9701	rho = 0.17 p = 0.1375	rho = 0.16 p = 0.1479	rho = 0.26 p = 0.0177	rho = −0.26 p = 0.0182	rho = 0.31 p = 0.0127
			Transf	rho = 0.33 p = 0.0030	rho = −0.15 p = 0.1744	rho = 0.41 p = 0.0002	rho = 0.22 p = 0.0508	rho = −0.17 p = 0.1304	rho = 0.30 p = 0.0145
				Alb	rho = −0.06 p = 0.5812	rho = 0.29 p = 0.0102	rho = 0.39 p = 0.0005	rho = −0.10 p = 0.3894	rho = 0.09 p = 0.4761
					IgG	rho = 0.11 p = 0.3177	rho = 0.35 p = 0.0016	rho= 0.39 p = 0.0003	rho = −0.10 p = 0.4353
						Hapto	rho = 0.45 p < 0.0001	rho = 0.04 p = 0.7341	rho = 0.22 p = 0.0790
							α1-acid	rho = 0.10 p = 0.3671	rho = 0.35 p = 0.0042
								PM 23.000	rho = −0.41 p = 0.0008
									CRP

[TFN1] Medians followed by the same uppercase letters within columns and lowercase letters within rows do not differ from each other by Dunn’s test (p>0.05).