Pharmaceutical and biological properties of <i>Stachys</i> species: A review

Kanjevac, Milica; Zlatić, Nenad; Bojović, Biljana; Stanković, Milan

doi:10.1590/s2175-97902022e20211

Tabla de contenido Anterior Actual Siguiente

Tabla de contenido

Article • Braz. J. Pharm. Sci. 58 • 2022 • https://doi.org/10.1590/s2175-97902022e20211 linkcopy

Pharmaceutical and biological properties of Stachys species: A review

Authorship SCIMAGO INSTITUTIONS RANKINGS

The genus Stachys includes about 300 cosmopolitan species, making it one of the largest genera of the Lamiaceae family. The purpose of this paper is to present a review of Stachys species in the flora of Serbia among which some species are endemic to the Balkan Peninsula. This review comprises morphological, phytochemical, medicinal and food application of 17 taxa: S. аlopecuros, S. аlpina, S. аnisochila, S. аnnua, S. аtherocalyx, S. cretica subsp. cassia, S. germanica, S. leucoglossa, S. milanii, S. officinalis, S. palustris, S. plumose, S. recta, S. tymphaea, S. scardica, S. serbica, and S. sylvatica. The species of the genus Stachys are rich sources of biologically active substances and well known for their worldwide application. For most of the Stachys species, it has been shown that their extracts possess biological activities such as antibacterial, anti-inflammatory, antioxidant, and anticancer. The main goals of this review include the morphological description of species, representation of the major secondary metabolites, and presentation of traditional knowledge in food preparation.

Keywords:
Essential oils; Medicinal application; Morphology; Secondary metabolites

Species	Secondary metabolites	Compound	References
S. alopecuros	Flavonoid heterozoids	Isoscutellarein 7-O-β-D-glucopyranoside	Marin et al., 2004.
S. alopecuros	Flavonoids	Apigenin 7-O-(6 ''-p-coumaroyl)-β-D-glucopyranoside	Marin et al., 2004.
S. alpine	Phenol carboxylic acids	Caffeic acid; Chlorogenic acid; Rosmarinic acid; Protocatechuic acid; Sinapic acid	Buchwald, Czapska, 1995; Bilušić Vundać et al., 2005; Buchwald, Czapska, 1995.
S. anisochila	Flavonoid heterozoids	Isoscutellarein 7-O-[6 '' '- acetyl-β-D-allopyranosyl (1-2)]-β-D-glucopyranoside; 4'-O-Methylisoskutelarein 7-O-[6 '' '- acetyl-β-D-allopyranosyl (1-2)]-β-D-glucopyranoside; 4'-O-Methyl hypo ethanol 7-O-[6 '' '- acetyl-β-D-allopyranosyl; (1-2)]-β-D-glucopyranoside; Hypolaetin 7-O-[6 '' '- acetyl-β-D-allopyranosyl (1-2)]-β-D-glucopyranoside	Marin et al., 2004; Lenherr, Meier, Sticher, 1984a; Lenherr, Mabry, 1987.
S. anisochila	Flavonoids	Apigenin 7-O-(6 ''-p-coumaroyl)-β-D-glucopyranoside	Marin et al., 2004.
S. annua	Flavonoid aglycones	Baicalin; 4′-O-methyl skutelarine	Sheremet, Komissarenko, 1971.
	Flavonoid heterozoids	Scutellarein 7-O-[β-D-man pyranosyl- (1-2)]-β-D-glucopyranoside (stachyflazide); 4'-O-Methylisoskutelarein 7-O-[6 '' '- acetyl-β-D-allopyranosyl (1-2)]-β-D-glucopyranoside; 4'-O-Methyl hypo ethanol 7-O-[6 '' '- acetyl-β-D-allopyranosyl (1-2)]-β-D-glucopyranoside	Lenherr, Meier, Sticher, 1984a; Sheremet, Komissarenko, 1971.
	Phenol carboxylic acids	Caffeic acid; Chlorogenic acid; Rosmarinic acid; Protocatechuic acid; Sinapic acid	Buchwald, Czapska, 1995; Czigle et al., 2007; Buchwald, Czapska, 1995.
	Diterpenes	Clerodane	Orgiyan, Popa, 1969.
S. atherocalyh	Flavonoid heterozoids	Isoscutellarein 7-O-[6 '' '- acetyl-β-D-allopyranosyl (1-2)]-β-D-glucopyranoside; Scutellarein 7-O-[β-D-mannopyranosyl-(1-2)]-β-D-glucopyranoside (stachyflazide)); 4'-O-Methylisoskutelarein 7-O-[6 '' '- acetyl-β-D-allopyranosyl (1-2)]-β-D-glucopyranoside; 4'-O-Methyl hypo ethanol 7-O-[6 '' '- acetyl-β-D-allopyranosyl (1-2)]-β-D-glucopyranoside	Lenherr, Meier, Sticher, 1984a; Komissarenko et al., 1976; Kostyuchenko et al., 1982; Lenherr, Meier, Sticher, 1984a;
	Phenol carboxylic acids	Caffeic acid; Chlorogenic acid; p-Coumaric acid	Kostyuchenko, 1982.
	Diterpenes	Clerodane	Piozzi, Bruno, 2011.
S. germanica	Flavonoid heterozoids	4'-O-Methylisoskutelarein 7-O-[6 '' '- acetyl-β-D-allopyranosyl (1-2)]-β-D-glucopyranoside	Bankova et al., 1999.
	Flavonoids	Apigenin 7-O-(6 ''-p-coumaroyl)-β-D-glucopyranoside	Marin et al., 2004.
	Phenylethane heteroids	Acteoside; Martinoside	Bankova et al., 1999.
	Phenol carboxylic acids	Caffeic acid; Chlorogenic acid; Rosmarinic acid; Protocatechuic acid; Sinapic acid	Buchwald, Czapska, 1995.
S. leucoglossa	Flavonoid heterozoids	Isoscutellarein 7-O-[6 '' '- acetyl-β-D-allopyranosyl (1-2)]-β-D-glucopyranoside; 4'-O-Methylisoskutelarein 7-O-[6 '' '- acetyl-β-D-allopyranosyl (1-2)] - β-D-glucopyranoside; 4'-O-Methyl hypo ethanol 7-O-[6 '' '- acetyl-β-D-allopyranosyl (1-2)]-β-D-glucopyranoside	Lenherr, Meier, Sticher,1984a;
S. officinalis	Flavonoid aglycones	Apigenin; 7-O-Methyltricin	El-Ansari et al., 1991. Kobzar, Nikonov, 1986.
	Flavonoids	Apigenin 7-O-(6 ''-p-coumaroyl)-β-D-glucopyranoside	Marin et al., 2004.
	Phenylethane heteroids	Acteoside; Martinoside; Betonioside F; Forsythoside B; Leucosceptoside B	Miyase, Yamamoto, Ueno, 1996a; Bankova et al., 1999.
	Phenol carboxylic acids	Caffeic acid; Chlorogenic acid; Isochlorogenic acid; Rosmarinic acid; p-Coumaric acid; Protocatechuic acid; Sinapic acid	Kobzar, 1986; Buchwald, Czapska, 1995; Bilušić Vundać et al., 2005; Czigle et al., 2007.
	Iridoidi	6-O-acetylmioporoside; Alobetonicoside	Jeker et al., 1989.
	Diterpenes	Clerodan	Bankova et al., 1999.
S. palustris	Flavonoids	Apigenin 7-O-(6 ''-p-coumaroyl)-β-D-glucopyranoside	Marin et al., 2004.
	Phenol carboxylic acids	Caffeic acid; Chlorogenic acid; Rosmarinic acid; Protocatechuic acid; Sinapic acid	Buchwald, Czapska, 1995; Czigle et al., 2007.
	Diterpenes	Clerodan	Piozzi, Bruno, 2011.
S. pulmosa	Flavonoid heterozoids	Isoscutellarein 7-O-[6 '' '- acetyl-β-D-allopyranosyl (1-2)]-β-D-glucopyranoside; 4'-O-Methylisoskutelarein 7-O-[6 '' '- acetyl-β-D-allopyranosyl (1-2)]-β-D-glucopyranoside	Marin et al., 2004; Bankova et al., 1999.
	Flavonoids	Apigenin 7-O-(6 ''-p-coumaroyl)-β-D-glucopyranoside	Marin et al., 2004.
	Phenylethane heteroids	Acteoside; Martinoside; Forsythoside B	Bankova et al., 1999.
	Diterpenes	Labdane	Paternostro et al., 2000.
S. recta	Flavonoid heterozoids	Isoscutellarein 7-O-[6 '' '- acetyl-β-D-allopyranosyl (1-2)]-β-D-glucopyranoside; 4'-O-Methylisoskutelarein 7-O- [6 '' '- acetyl-β-D-allopyranosyl (1-2)]-β-D-glucopyranoside; 4'-O-Methyl hypo ethanol 7-O-[6 '' '- acetyl-β-D-allopyranosyl (1-2)]-β-D-glucopyranoside	Marin et al., 2004; Lenherr, Meier, Sticher, 1984a; Lenherr, Lahloub, Stcher, 1984b.
	Flavonoids	Apigenin 7-O-(6 ''-p-coumaroyl)-β-D-glucopyranoside; Apigenin 7-O-(3 ''-p-coumaroyl)-β-D-glucopyranoside	Karioti et al., 2010.
	Phenol carboxylic acids	Caffeic acid; Chlorogenic acid; Rosmarinic acid; p-Coumaric acid; Protocatechuic acid; Sinapic acid	Buchwald, Czapska, 1995; Czigle et al., 2007.
	Diterpenes	Clerodan	Adinolfi et al., 1984.
S. sylvatica	Flavonoid heterozoids	4'-O-Methylisoskutelarein 7-O-[6 '' '- acetyl-β-D-allopyranosyl (1-2)] - β-D-glucopyranoside	Bankova et al., 1999.
	Flavonoids	Apigenin 7-O-(6 ''-p-coumaroyl)-β-D-glucopyranoside	Marin et al., 2004.
	Phenylethane heteroids	Acteoside; Martinoside; Forsythoside B	Bankova et al., 1999.
	Phenol carboxylic acids	Caffeic acid; Chlorogenic acid; Rosmarinic acid; p-Coumaric acid; Protocatechuic acid; Sinapic acid	Buchwald, Czapska, 1995; Bilušić Vundać et al., 2005; Czigle et al., 2007.
	Diterpenes	Kauran; Clerodan	Popa, Pasechnik, 1974; Piozzi, Bruno, 2011.

location_on

Universidade de São Paulo, Faculdade de Ciências Farmacêuticas Av. Prof. Lineu Prestes, n. 580, 05508-000 S. Paulo/SP Brasil, Tel.: (55 11) 3091-3824 - São Paulo - SP - Brazil
E-mail: bjps@usp.br

rss_feed Acompañe los números de esta revista en su lector de RSS