TRATAMENTO DE PACIENTES COM TUMOR ÓSSEO DE CÉLULAS GIGANTES NO NORTE DO BRASIL, EM 2020 E 2021

Couto Filho, Fernando Brasil do; Yonamine, Eduardo Sadao; Magno, Felipe Guimarães; Favacho-Silva, Ana Beatriz; Brito, Carlos Rafael Alves de; Brito, Thiago Raphael Brasil

doi:10.1590/1413-785220253301e285342

person Fernando Brasil do Couto Filho

critical revision of its intellectual content and final approval · contributed individually and significantly to the development of this article

schoolHospital Ophir Loyola, Orthopaedic Oncology Department, Belém, PA, Brazil

0000-0003-2807-7600

person Eduardo Sadao Yonamine

critical revision of its intellectual content and final approval · contributed individually and significantly to the development of this article

schoolSanta Casa de Misericórdia de São Paulo, Orthopaedic Oncology Department, São Paulo, SP, Brazil

0000-0001-6924-2647

person Felipe Guimarães Magno

contribution to the conception of the word, critical revision of its intellectual content, and final approval · contributed individually and significantly to the development of this article

schoolHospital Ophir Loyola, Orthopaedic Oncology Department, Belém, PA, BrazilschoolSanta Casa de Misericórdia de São Paulo, Orthopaedic Oncology Department, São Paulo, SP, Brazil

0009-0009-0078-4507

person Ana Beatriz Favacho-Silva

contribution to conception, analysis, and interpretation of data for the work · drafting the work and critical revision of its intellectual content · contributed individually and significantly to the development of this article

schoolHospital Ophir Loyola, Orthopaedic Oncology Department, Belém, PA, Brazil

0000-0001-5414-995X

person Carlos Rafael Alves de Brito

contribution to conception and analysis of the work, drafting the work · contributed individually and significantly to the development of this article

schoolHospital Ophir Loyola, Orthopaedic Oncology Department, Belém, PA, Brazil

0009-0001-5726-7780

person Thiago Raphael Brasil Brito

contribution to conception and analysis of the work, drafting the work · contributed individually and significantly to the development of this article

schoolHospital Ophir Loyola, Orthopaedic Oncology Department, Belém, PA, Brazil

0000-0003-1455-8868

Correspondence: Fernando Brasil do Couto Filho. 2000, Centenário Ave., Condomínio Água Cristal, Alameda Beijupirá, n. 16., Bairro Mangueirão, Belém, PA, Brazil. 66640-658.
fernandobrasilfilho@gmail.com

All authors declare no potential conflict of interest related to this article.

The study was conducted at Ophir Loyola Hospital.

Variable	Frequency (n. 19)	Percentage (%)	CI95%
Sex
Male	11	57.89	36.8 - 78.9
Female	8	42.11	21.1 - 63.2
Age (years)
Mean ( sd)	37.32 ( 13.47)		31.0 - 43.8
Median (p25-75%)	39.00 (24.00 - 45.50)		24.0 - 44.0
Age range
< 30 years	6	31.58	10.5 - 52.6
≥ 30 years	13	68.42	47.4 - 89.5
Location
Metropolitan region of Belém	6	31.58	10.5 - 52.6
Other regions of Pará	9	47.37	26.3 - 68.4
Other state	4	21.05	5.3 - 42.1
Patient delay (months)
Mean ( sd)	10.47 ( 13.08)		6.1 - 17.1
Median (p25-75%)	7.00 (4.00 - 12.00)		4.0 - 12.0
Patient delay ≥ 12 months
Yes	6	31.58	10.5 - 52.6
No	13	68.42	47.4 - 89.5
Anatomic location
Proximal femur	1	5.26	0.0 - 15.8
Distal femur	9	47.37	21.2 - 68.4
Proximal tibia	6	31.58	10.5 - 52.6
Calcaneus	1	5.26	0.0 - 15.8
Hand bones	2	10.53	0.0 - 26.3
Campanacci
Stage 1	2	10.53	0.0 - 26.3
Stage 2	3	15.79	0.0 - 31.6
Stage 3	14	73.68	52.5 - 89.5
Pathological fracture
Yes	3	15.79	0.0 - 36.8
No	16	84.21	63.2 - 100.0
Surgery type
Wide resection	14	73.68	52.5 - 89.5
Marginal/Intralesional	3	15.79	0.0 - 31.6
Not performed	2	10.53	0.0 - 26.3
Recurrence
Yes	3	15.79	0.0 - 36.8
No	16	84.21	63.2 - 100.0
Denosumab use
Yes	5	26.32	10.5 - 47.4
No	14	73.68	52.5 - 89.5
Pulmonary metastasis
Yes	0	0.00	0.0 - 0.0
No	19	100.00	100.0 - 100.0

Variable	Stage 1 e 2 (n. 5)	Stage 3 (n. 14)	p-value
Sex
Male	1(20.0%)	10(71.4%)	0.071^a
Female	4(80.0%)	4(28.6%)	0.071^a
Age(years)
Mean( sd)	38.6( 9.6)	36.8( 14.9)	0.830^b
Median(p25-75%)	39.0(39.0-43.0)	36.5(24.0-47.0)	0.830^b
Agerange
<30years	1(20.0%)	5(35.7%)	0.480^a
>30years	4(80.0%)	9(64.9%)	0.480^a
Location
MetropolitanregionofBelém	1(20.0%)	5(35.7%)	0.814^a
OtherregionsofPará	3(60.0%)	6(42.9%)
Otherstate	1(20.0%)	3(21.4%)
Patientdelay
Mean( sd)	14.0( 25.7)	9.2( 5.2)	0.070^b
Median(p25-75%)	3.0(2.0-4.0)	7.5(6.0-12.0)	0.070^b
Patientdelay≥12months
Yes	1(20.0%)	5(35.7%)	0.631^a
No	4(80.0%)	9(64.3%)	0.631^a
Anatomiclocation
Proximalfemur	0(0.0%)	1(7.1%)	0.164^a
Distalfemur	3(60.0%)	6(42.9%)
Proximaltibia	0(0.0%)	6(42.9%)
Calcaneus	1(20.0%)	0(0.0%)
Handbones	1(20.0%)	1(7.1%)
Pathologicalfracture
Yes	0(0.0%)	3(21.4%)	0.530^a
No	5(100.0%)	11(78.6%)	0.530^a
Surgerytype
Wideresection	1(20.0%)	13(92.9%)	0.002^a*
Marginal/Intralesional	3(60.0%)	0(0.0%)
Notperformed	1(20.0%)	1(7.1%)
Recurrence
Yes	0(0.0%)	3(21.4%)	0.530^a
No	5(100.0%)	11(78.6%)	0.530^a
Denosumabuse
Yes	0(0.0%)	5(35.7%)	0.257^a
No	5(100.0%)	9(64.3%)	0.257^a
Pulmonarymetastasis
Yes	0(0.0%)	0(0.0%)	1.000^a
No	5(100.0%)	14(100.0%)	1.000^a

[TFN1] Sd: Standard deviation. P: Percentile. CI: confidence interval.