PHYSICAL ACTIVITY IN DAILY LIFE, EXERCISE CAPACITY AND QUALITY OF LIFE IN PATIENTS WITH CROHN’S DISEASE ON INFLIXIMAB-INDUCED REMISSION: A PRELIMINARY STUDY

CABALZAR, Andrea Lemos; AZEVEDO, Felipe Meirelles de; LUCCA, Fernando de Azevedo; REBOREDO, Maycon de Moura; MALAGUTI, Carla; CHEBLI, Júlio Maria Fonseca

doi:10.1590/S0004-2803.201900000-65

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ORIGINAL ARTICLE • Arq. Gastroenterol. 56 (4) • Oct-Dec 2019 • https://doi.org/10.1590/S0004-2803.201900000-65 linkcopy

PHYSICAL ACTIVITY IN DAILY LIFE, EXERCISE CAPACITY AND QUALITY OF LIFE IN PATIENTS WITH CROHN’S DISEASE ON INFLIXIMAB-INDUCED REMISSION: A PRELIMINARY STUDY

Atividade física de vida diária, capacidade de exercício e qualidade de vida de pacientes com doença de Crohn em remissão induzida por infliximabe: um estudo preliminar

Authorship SCIMAGO INSTITUTIONS RANKINGS

BACKGROUND: Physical activity in daily life and exercise capacity have not been assessed in patients with Crohn’s disease to date.

OBJECTIVE: To evaluate the physical activity in daily life, exercise capacity, quality of life, and prevalence of mood disorders in patients with moderate-to-severe Crohn’s disease on infliximab-induced remission and the possible associations among variables.

METHODS: A cross-sectional preliminary study was conducted. Twenty-six patients with Crohn’s disease and 20 controls were selected. Participants underwent evaluation of physical activity in daily life (triaxial accelerometer), exercise capacity (shuttle walk test), handgrip strength, quality of life, and presence of mood disorders.

RESULTS: The number of steps taken (7446±3081 vs 7898±2487), active time (80.6±42 vs 89.7±24.3min), shuttle walk test distance [665 (405) vs 710 (409) m] and handgrip strength [31 (15) vs 29 (20) kgf did not show any difference between the patients with Crohn’s disease and the controls. The time spent lying down [95.8 (68.8) vs 60.9 (74.7) min] was greater and some domains of the quality of life were superior in the patients with Crohn’s disease. No correlation was observed between the physical activity in daily life and quality of life or presence of mood disorders in patients with Crohn’s disease.

CONCLUSION: Patients with Crohn’s disease on infliximab-induced remission, despite to more time spent lying down, they have the same level of physical activity in daily life and exercise capacity min compared with the controls.

HEADINGS:
Crohn disease; Exercise tolerance; Exercise

	CD (n=26)	Control	P values
		(n=20)
Gender
Female	14 (53.8)	12 (60.0)	0.68
Male	12 (46.2)	8 (40.0)

Race
Caucasian	25 (96.2)	17 (85.0)	0.19
Non-white	1 (3.8)	3 (15.0)

Age (years)	40.4 ± 12.7	38.6 ± 14.3	0.66
Body mass index (kg/m²)	23.5 ± 2.8	27.6 ± 4.9	0.001
Smokers (n, %)	8 (30.7)	4 (20)	0.19
Formal work (n, %)	12 (46.1)	11 (55.0)	0.56
HBI	1 (4.0)	-	-

IBDQ domains
Intestinal symptom	64.0 (44.0)	-	-
Systemic symptom	29.5 (20.0)	-	-
Social function	33.0 (22.0)	-	-
Emotional function	70.0 (39.0)	-	-
Total	198.5 (113.0)	-	-

Phenotype of CD
B1 (n, %)	11 (42.3)	-	-
B2 (n, %)	7 (26.9)	-	-
B3 (n, %)	8 (30.7)	-	-

Disease location
L1 (n, %)	6 (23.1)	-	-
L2 (n, %)	4 (15.4)	-	-
L3 (n, %)	14 (53.8)	-	-
L4 (n, %)	2 (7.7)	-	-
Disease duration (years)	4 (21.5)	-	-

Perianal disease (n, %)	5 (19.2)	-	-
Previous intestinal resection (n, %)	7 (26.9)	-	-

	CD Group	Control Group	P values
	(n=26)	(n=20)
SF-36 domains
Functional capacity	95 (50.0)	95 (85.0)	0.82
Physical aspects	100 (100.0)	100 (100.0)	0.30
Pain	78 (80.0)	46 (100.0)	0.003
General health status	67 (70.0)	58.5 (52.0)	0.32
Vitality	70 (80.0)	60 (70.0)	0.03
Social aspects	93.7 (75.0)	56.2 (100.0)	0.03
Emotional aspects	100 (100.0)	100 (100.0)	0.23
Mental health	76 (68.0)	68 (80.0)	0.04
HADS
Anxiety	6 (14.0)	7 (17.0)	0.07
Depression	3 (9.0)	5 (15.0)	0.09

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[TFN1] Data expressed as absolute and relative values and mean ± SD or median (interquartile range) for symmetrically and asymmetrically distributed data, respectively.

[TFN2] HBI: Harvey-Brashaw index; L1: ileal; L2: colonic; L3: ileocolonic; L4: isolated upper digestive; B1: non-stricturing, non-penetrating; B2: stricturing; B3: penetrating; IBDQ: inflammatory bowel disease questionnaire.