Urethral dysfunction due to alloxan-induced diabetes. Urodynamic evaluation and action of sildenafil citrate¹

Abstract

PURPOSE:  To evaluate the effect of diabetes mellitus and of sildenafil citrate on female urethral function.

METHODS:  Twenty nine female rats were divided into four groups: G1 - (n=9), normal rats; G2 - (n=6), normal rats treated with sildenafil citrate; G3 - (n=9) rats with alloxan-induced diabetes; G4 - (n=5) rats with alloxan-induced diabetes treated with sildenafil citrate. Under anesthesia, urodynamic evaluation was performed by cystometry and urethral pressure simultaneously.

RESULTS:  A significant increase in urethral pressure was observed during micturition.

CONCLUSION:  Sildenafil citrate can partially reduced urethral pressure in diabetic female rats.

Diabetes Mellitus; Urethra; Urinary Bladder; Rats