Morning glory disc anomaly and irregular optic nerve thickness: an overlooked association

Alves Júnior, Sérgio Ferreira; Teixeira, Luiz Fernando; Manso, Paulo Gois; Corrêa, Diogo Goulart; Monteiro, Soraya Silveira; Fonseca, José Roberto Falco

doi:10.5935/0004-2749.2024-0330

A 2-year-old patient had right ocular esotropia for 1.5 years. Right fundoscopy revealed a large disc, central glial tuft (arrow), and a halo of pigmentary changes in the peripapillary area surrounding the nerve (arrowhead) consistent with methylglycinediacetic acid (MGDA) (Figure 1A). Funnel-shaped morphology of the optic disc (black arrow), adjacent retinal surface elevation and enhancement (red arrow), and irregular thickening of the nerve (blue arrowheads) were detected (Figure 1B, Figure 1C). Irregular thickness of optic nerve occurs in 89% MGDA, the nature being uncertain(¹-³).

Informed consent was obtained from all patients included in this study.
Funding:
This study received no specific financial support.

REFERENCES

¹ Ellika S, Robson CD, Heidary G, Paldino MJ. Morning glory disc anomaly: characteristic MR imaging findings. AJNR Am J Neuroradiol. 2013;34(10):2010-4.
² Nguyen DT, Boddaert N, Bremond-Gignac D, Robert MP. Optic nerve abnormalities in morning glory disc anomaly: an MRI study. J Neuroophthalmol. 2022;42(2):199-202.
³ Doneda C, Pinelli L, Scaramuzzi M, Galli J, Fazzi E, Parazzini C, et al. Morning glory disc anomaly associated with ipsilateral optic nerve and chiasm thickening: three cases and review of the literature. Neuropediatrics. 2017;48(6):463-6.

Publication Dates

Publication in this collection
28 Apr 2025
Date of issue
2025

History

Received
03 Dec 2024
Accepted
16 Jan 2025

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

[1] ¹ Ellika S, Robson CD, Heidary G, Paldino MJ. Morning glory disc anomaly: characteristic MR imaging findings. AJNR Am J Neuroradiol. 2013;34(10):2010-4.

[2] ² Nguyen DT, Boddaert N, Bremond-Gignac D, Robert MP. Optic nerve abnormalities in morning glory disc anomaly: an MRI study. J Neuroophthalmol. 2022;42(2):199-202.

[3] ³ Doneda C, Pinelli L, Scaramuzzi M, Galli J, Fazzi E, Parazzini C, et al. Morning glory disc anomaly associated with ipsilateral optic nerve and chiasm thickening: three cases and review of the literature. Neuropediatrics. 2017;48(6):463-6.