Cutaneous T-cell lymphomas in the revised 4<sup>th</sup> edition of World Health Organization classification of tumors of hematopoietic and lymphoid tissues (2017)

Xavier Júnior, Jose Candido Caldeira; Ocanha-Xavier, Juliana Polizel

doi:10.1590/abd1806-4841.20188057

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Dermatopathology • An. Bras. Dermatol. 93 (6) • Nov/Dec 2018 • https://doi.org/10.1590/abd1806-4841.20188057 linkcopy

Cutaneous T-cell lymphomas in the revised 4^th edition of World Health Organization classification of tumors of hematopoietic and lymphoid tissues (2017)^*

Authorship SCIMAGO INSTITUTIONS RANKINGS

Recently, the World Health Organization published the revised 4th edition of its classification of tumors of hematopoietic and lymphoid tissues. The present paper is a concise comparative review of the main primary cutaneous T-cell hematopoietic tumors, with emphasis on their immunohistochemical profiles.

Keywords:
Dermatology; Immunohistochemistry; Lymphoma, T-Cell, cutaneous; Pathology

Type	Frequency	Histology	Immunohistochemistry
A	>80%	Sparse large and atypical neoplastic cells amid mixed inflammatory infiltrate	CD4+, CD8-
B*	<5%	Epidermotropic Infiltrate of small lymphocytes	CD4+, CD8-
C	~10%	Cohesive infiltrate of large and atypical cells among sparse inflammatory cells	CD4+, CD8-
D	<5%	Infiltration of small and medium atypical epider- motropic cells.	CD4-, CD8+
E	<5%	Angiocentric and angiodestructive pattern	CD4-, CD8+
Rearrangement DUSP22-IRF4	<5%	Small and epidermotropic lymphocytes associated with large neoplastic cells in the dermis (similar to transforming MF)	CD4-, CD8+ ou CD4-, CD8-

Disease	CD3	CD4	CD8	Cytotoxic markersa	CD56	EBV	CD30
MF	+	+	-/+	-	-	-	-/+
LyP	+	+/-	-/+	+/-	-	-	+
C-ALCL	+	+/-	-/+	+/-	-	-	+
SPTCL	+	-	+	+	-	-	-
PCGD-TCL	+	-	-/+	+	+	-	-
AECTCL	+	-	+	+	-/+	-	-
CD8+ LP	+	-	+	-b	-	-	-
PCSM-TCLD	+	+	-	-	-	-	-
HVLD	+	-/+	+	+	+	+	+/-

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[TFN01] LyP type B can be negative for CD30.

[TFN02] Source: Swerdlow, et al., 2017.¹

Cutaneous T-cell lymphomas in the revised 4th edition of World Health Organization classification of tumors of hematopoietic and lymphoid tissues (2017)*

Cutaneous T-cell lymphomas in the revised 4^th edition of World Health Organization classification of tumors of hematopoietic and lymphoid tissues (2017)^*