Cutaneous leukocytoclastic vasculitis in the presence of methimazole therapy

Ribeiro, Carla de Oliveira; Magrin, Paula Ferrazzi; Vilar, Enoí Aparecida Guedes; Durães, Sandra Maria Barbosa; Estrella, Rogério Ribeiro

doi:10.1590/S0365-05962013000200021

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Case Report • An. bras. dermatol. 88 (2) • Apr 2013 • https://doi.org/10.1590/S0365-05962013000200021 linkcopy

Cutaneous leukocytoclastic vasculitis in the presence of methimazole therapy^*

Vasculite leucocitoclástica cutânea na vigência de terapêutica com metimazol

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

Treatment with antithyroid drugs may be accompanied by side effects. We present a patient diagnosed with Grave's Disease who developed extensive vasculitis in the lower limbs during methimazole use. After suspension of the methimazole and the introduction of prednisone in immunesupressor doses the cutaneous lesions started to involute.

Anti-neutrophil cytoplasmic antibody-associated vasculitis; Methimazole; Vasculitis; Cutaneous leukocytoclastic vasculitis

Laboratory data	Results	Reference value
TSH	0,08 UI/ml	0,4-6,0 UI/ml

T4	2,82 ug/dl	4,5-12,5 ug/dl

Anti-TPO	674,8 UI/ml	< 40 UI/ml- Negative, 40-100 UI/ml-Borderline, >100 UI/ml- Positive

Anti-thyroglobulin	21,8 UI/ml	<75 UI/ml- Negative, 75-100 UI/ml Borderline, >100 UI/ml- Positive

FAN	Non reactive	Non reactive

P-ANCA	12 U/ml	Positive> 5 U/ml

C-ANCA	Negative	Positive> 5 U/ml

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Cutaneous leukocytoclastic vasculitis in the presence of methimazole therapy*

Vasculite leucocitoclástica cutânea na vigência de terapêutica com metimazol

Abstract

Cutaneous leukocytoclastic vasculitis in the presence of methimazole therapy^*