Red cabbage <i>(Brassica oleracea</i> L.) extract reverses lipid oxidative stress in rats

VEBER, BRUNO; CAMARGO, ANDERSON; DALMAGRO, ANA PAULA; BONDE, HENRIQUE LUIS P.; MAGRO, DÉBORA D. DAL; LIMA, DANIELA D. DE; ZENI, ANA LÚCIA B.

doi:10.1590/0001-3765202020180596

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Biological Sciences • An. Acad. Bras. Ciênc. 92 (01) • 2020 • https://doi.org/10.1590/0001-3765202020180596 linkcopy

Red cabbage (Brassica oleracea L.) extract reverses lipid oxidative stress in rats

Authorship SCIMAGO INSTITUTIONS RANKINGS

Red cabbage (Brassica oleracea L. var. capitata f. rubra DC.) extract has been demonstrated hypolipidemic and antioxidant capacity. Herein, we investigated the effect of red cabbage aqueous extract (RC) or fenofibrate (FF) in oxidative stress induced by Triton WR-1339 in rats. The antioxidant capacity was evaluated through the superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) activities and, thiobarbituric reactive species (TBARS) and protein carbonyl (PC) levels in erythrocytes, liver, kidneys, cerebral cortex and hippocampus of male rats. The alterations promoted by Triton WR-1339 in enzymatic antioxidant defense in the liver, kidneys and hippocampus were reversed by RC or FF treatments. The TBARS and PC levels increased in the liver, cerebral cortex and hippocampus of hyperlipidemic rats were decreased by the treatments with RC or FF. These findings demonstrated that RC is a potential therapy to treat diseases not only involving dyslipidemic condition but also oxidative stress.

Key words
red cabbage; Brassica oleracea; oxidative stress; antioxidants; Triton WR-1339

Authorship

person BRUNO VEBER

schoolLaboratório de Avaliação de Substâncias Bioativas, Departamento de Ciências Naturais, Universidade Regional de Blumenau, Rua Antônio da Veiga, 140, Victor Konder, 89030-903 Blumenau, SC, Brazil Universidade Regional de BlumenauBrazilBlumenau, SC, BrazilLaboratório de Avaliação de Substâncias Bioativas, Departamento de Ciências Naturais, Universidade Regional de Blumenau, Rua Antônio da Veiga, 140, Victor Konder, 89030-903 Blumenau, SC, Brazil

0000-0002-5206-3471

person ANDERSON CAMARGO

0000-0002-1632-4865

person ANA PAULA DALMAGRO

0000-0001-6969-7473

person HENRIQUE LUIS P. BONDE

schoolLaboratório de Biofísica, Departamento de Ciências Naturais, Universidade Regional de Blumenau, Rua Antônio da Veiga, 140, Victor Konder, 89030-903 Blumenau, SC, Brazil Universidade Regional de BlumenauBrazilBlumenau, SC, BrazilLaboratório de Biofísica, Departamento de Ciências Naturais, Universidade Regional de Blumenau, Rua Antônio da Veiga, 140, Victor Konder, 89030-903 Blumenau, SC, Brazil

0000-0002-3977-6717

person DÉBORA D. DAL MAGRO

0000-0003-4459-1562

person DANIELA D. DE LIMA

schoolDepartamento de Medicina, Universidade da Região de Joinville, Rua Paulo Malschitzki, 10, Zona Industrial Norte, 89219-710 Joinville, SC, Brazil Universidade da Região de JoinvilleBrazilJoinville, SC, BrazilDepartamento de Medicina, Universidade da Região de Joinville, Rua Paulo Malschitzki, 10, Zona Industrial Norte, 89219-710 Joinville, SC, Brazil

0000-0001-5335-5102

person ANA LÚCIA B. ZENI

0000-0002-9904-9861

Correspondence to Ana Lúcia Bertarello Zeni E-mail:
anazeni@furb.br

AUTHOR CONTRIBUTIONS

BV performed experiments, collected samples, analyzed data and co-wrote the paper. AC and APD performed experiments and co-wrote the paper. BG collected samples, performed experiments and co-wrote the paper. DDDM and DDL supervised the research, designed experiments and co-wrote the paper. ALBZ supervised the research, designed experiments, analyzed data and co-wrote the paper.

SCIMAGO INSTITUTIONS RANKINGS

Laboratório de Avaliação de Substâncias Bioativas, Departamento de Ciências Naturais, Universidade Regional de Blumenau, Rua Antônio da Veiga, 140, Victor Konder, 89030-903 Blumenau, SC, Brazil Universidade Regional de BlumenauBrazilBlumenau, SC, BrazilLaboratório de Avaliação de Substâncias Bioativas, Departamento de Ciências Naturais, Universidade Regional de Blumenau, Rua Antônio da Veiga, 140, Victor Konder, 89030-903 Blumenau, SC, Brazil

Laboratório de Biofísica, Departamento de Ciências Naturais, Universidade Regional de Blumenau, Rua Antônio da Veiga, 140, Victor Konder, 89030-903 Blumenau, SC, Brazil Universidade Regional de BlumenauBrazilBlumenau, SC, BrazilLaboratório de Biofísica, Departamento de Ciências Naturais, Universidade Regional de Blumenau, Rua Antônio da Veiga, 140, Victor Konder, 89030-903 Blumenau, SC, Brazil

Departamento de Medicina, Universidade da Região de Joinville, Rua Paulo Malschitzki, 10, Zona Industrial Norte, 89219-710 Joinville, SC, Brazil Universidade da Região de JoinvilleBrazilJoinville, SC, BrazilDepartamento de Medicina, Universidade da Região de Joinville, Rua Paulo Malschitzki, 10, Zona Industrial Norte, 89219-710 Joinville, SC, Brazil

Figures

Figures (5)

Thumbnail

Figure 1 Effects of red cabbage aqueous extract (RC) and fenofibrate (FF) treatments on oxidative stress markers in kidneys (left, panels a and d), liver (middle, panels b and e) and serum (right, panels c and f) of Triton WR-1339-induced hyperlipidemia in rats. Bars represent means± S.D. (n=5–6). *p<0.05, **p<0.001, ***p<0.001 vs normal control (NC) and #p<0.05, ##p<0.01, ###p<0.001 vs Triton control (TC), according to one-way ANOVA followed by the Tukey’s post hoc test. MDA= malondialdehyde.

Thumbnail

Figure 2 Effects of red cabbage aqueous extract (RC) and fenofibrate (FF) treatments on oxidative stress markers in cerebral cortex (left, panels a and c) and hippocampus (right, panels b and d) of Triton WR-1339-induced hyperlipidemia in rats. Bars represent means± S.D. (n=5–6). **p<0.001, ***p<0.001 vs normal control (NC) and #p<0.05, ##p<0.01, ###p<0.001 vs Triton control (TC), according to one-way ANOVA followed by Tukey’s test. MDA= malondialdehyde.

Thumbnail

Figure 3 Effects of red cabbage aqueous extract (RC) and fenofibrate (FF) treatments on antioxidant enzymes activities in kidneys (left, panels a, d and g), liver (middle, panels b, e and h) and erythrocytes (right, panels c, f and i) of Triton WR-1339-induced hyperlipidemia in rats. Bars represent means± S.D. (n=5–6). **p<0.001, ***p<0.001 vs normal control (NC) and ##p<0.01, ###p<0.001 vs Triton control (TC), according to one-way ANOVA followed by Tukey’s test. SOD= superoxide dismutase; CAT= catalase; GSH-Px= glutathione peroxidase.

Thumbnail

Figure 4 Effects of red cabbage aqueous extract (RC) and fenofibrate (FF) treatments on antioxidant enzymes activities in cerebral cortex (left, panels a, c and e) and hippocampus (right, panels b, d and f) of Triton WR-1339-induced hyperlipidemia in rats. Bars represent means± S.D. (n=5–6). ***p<0.001 vs normal control (NC) and ###p<0.001 vs Triton control (TC), according to one-way ANOVA followed by Tukey’s test. SOD= superoxide dismutase; CAT= catalase; GSH-Px= glutathione peroxidase.

Thumbnail

Figure 5 The schematic diagram shows biochemical pathways underlying Triton WR-1339-induced lipid oxidative stress and the antioxidant effects of RC and FF, a PPARα agonist. In this study, the RC and FF counteracted the alterations induced by Triton beyond the decrement of TBARS and PC levels normalizing the enzyme activities. CAT=catalase; FF= fenofibrate; GSH-Px= glutathione peroxidase; LPL= lipoprotein lipase; PPARα= Peroxisome proliferator-activated receptor alpha; PC= protein carbonyl; RC= red cabbage aqueous extract; SOD= superoxide dismutase; TBARS=thiobarbituric acid reactive substances.

imageFigure 1 Effects of red cabbage aqueous extract (RC) and fenofibrate (FF) treatments on oxidative stress markers in kidneys (left, panels a and d), liver (middle, panels b and e) and serum (right, panels c and f) of Triton WR-1339-induced hyperlipidemia in rats. Bars represent means± S.D. (n=5–6). p<0.05, p<0.001, p<0.001 vs normal control (NC) and #p<0.05, ##p<0.01, ###p<0.001 vs Triton control (TC), according to one-way ANOVA followed by the Tukey’s post hoc test. MDA= malondialdehyde. open_in_new

imageFigure 2 Effects of red cabbage aqueous extract (RC) and fenofibrate (FF) treatments on oxidative stress markers in cerebral cortex (left, panels a and c) and hippocampus (right, panels b and d) of Triton WR-1339-induced hyperlipidemia in rats. Bars represent means± S.D. (n=5–6). p<0.001, *p<0.001 vs normal control (NC) and #p<0.05, ##p<0.01, ###p<0.001 vs Triton control (TC), according to one-way ANOVA followed by Tukey’s test. MDA= malondialdehyde. open_in_new

imageFigure 3 Effects of red cabbage aqueous extract (RC) and fenofibrate (FF) treatments on antioxidant enzymes activities in kidneys (left, panels a, d and g), liver (middle, panels b, e and h) and erythrocytes (right, panels c, f and i) of Triton WR-1339-induced hyperlipidemia in rats. Bars represent means± S.D. (n=5–6). p<0.001, *p<0.001 vs normal control (NC) and ##p<0.01, ###p<0.001 vs Triton control (TC), according to one-way ANOVA followed by Tukey’s test. SOD= superoxide dismutase; CAT= catalase; GSH-Px= glutathione peroxidase. open_in_new

imageFigure 4 Effects of red cabbage aqueous extract (RC) and fenofibrate (FF) treatments on antioxidant enzymes activities in cerebral cortex (left, panels a, c and e) and hippocampus (right, panels b, d and f) of Triton WR-1339-induced hyperlipidemia in rats. Bars represent means± S.D. (n=5–6). ***p<0.001 vs normal control (NC) and ###p<0.001 vs Triton control (TC), according to one-way ANOVA followed by Tukey’s test. SOD= superoxide dismutase; CAT= catalase; GSH-Px= glutathione peroxidase. open_in_new

imageFigure 5 The schematic diagram shows biochemical pathways underlying Triton WR-1339-induced lipid oxidative stress and the antioxidant effects of RC and FF, a PPARα agonist. In this study, the RC and FF counteracted the alterations induced by Triton beyond the decrement of TBARS and PC levels normalizing the enzyme activities. CAT=catalase; FF= fenofibrate; GSH-Px= glutathione peroxidase; LPL= lipoprotein lipase; PPARα= Peroxisome proliferator-activated receptor alpha; PC= protein carbonyl; RC= red cabbage aqueous extract; SOD= superoxide dismutase; TBARS=thiobarbituric acid reactive substances. open_in_new

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