@article{silva_leão_schaeffer_cavalcante_souza_2026,  title={The 2025 FDA Small-Molecule Portfolio: Clinical Applications, Synthetic Approaches, Challenges, and Solutions},  volume={37},  ISSN={0103-5053},  url={https://doi.org/10.21577/0103-5053.20260042},  DOI={10.21577/0103-5053.20260042},  journal={Journal of the Brazilian Chemical Society},  publisher={Sociedade Brasileira de Química},  author={Silva, Felipe L. N. da and Leão, Raquel A. C. and Schaeffer, Edgar and Cavalcante, Samir F. A. and Souza, Rodrigo O. M. A. de},  year={2026},  pages={e–20260042} }